黄河干流白银市水川段水面线计算方法对比分析

为克服能量方程逐段试算方法在河道水面线计算上存在的不足与局限,本文以黄河干流白银市水川段为例,采用二维水动力数值计算模型,对4种洪水频率工况下黄河干流白银市段的水面线高程进行计算,并将二维数值计算结果与能量方程计算结果进行复核和评价。经计算可知两种计算方法在计算结果上存在偏差,能量方程在河道水面线计算上是一种近似成果,而二维数值计算能够更加真实反映河道的实际情况,因此在水面线计算时推荐二维数值计算方法。     

A Further Comparison of Splitting Rules for Decision-Tree Induction

One approach to learning classification rules from examples is to build decision trees. A review and comparison paper by Mingers (Mingers, 1989) looked at the first stage of tree building, which uses a splitting rule to grow trees with a greedy recursive partitioning algorithm. That paper considered a number of different measures and experimentally examined their behavior on four domains. The main conclusion was that a random splitting rule does not significantly decrease classificational accuracy. This note suggests an alternative experimental method and presents additional results on further domains. Our results indicate that random splitting leads to increased error. These results are at variance with those presented by Mingers.     

Physiological arousal, dissonance, and attitude change: Evidence for a dissonance-arousal link and a "Don't remind me" effect.

Two experiments, with 80 undergraduates, replicated and extended research by R. T. Croyle and J. Cooper (see record 1984-11595-001) indicating that cognitive dissonance involves physiological arousal. In Exp I, Ss wrote counterattitudinal essays under conditions of high or low choice and, to assess arousal effects owing to effort, with or without a list of arguments provided by the experimenter. In high-choice conditions only and regardless of effort, Ss showed both arousal (heightened galvanic skin response) and attitude change. Arousal, however, did not decline following attitude change. The more effortful task (no arguments provided) produced increased arousal but not greater attitude change. In Exp II, the opportunity to change one's attitude following a freely chosen counterattitudinal essay was manipulated. As in Exp I, arousal increased following the essay but did not decline following a postessay attitude change opportunity. When Ss were not given an attitude change opportunity, however, arousal did decline. It is suggested that if dissonance is a drive state, drive reduction typically may be accomplished through gradual cognitive change or forgetting. (47 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A Holistic Evolutionary and 3D Pharmacophore Modelling Study Provides Insights into the Metabolism,Function, and Substrate Selectivity of the Human Monocarboxylate Transporter 4 (hMCT4)

Monocarboxylate transporters (MCTs) are of great research interest for their role in cancer cell metabolism and their potential ability to transport pharmacologically relevant compounds across the membrane. Each member of the MCT family could potentially provide novel therapeutic approaches to various diseases. The major differences among MCTs are related to each of their specific metabolic roles, their relative substrate and inhibitor affinities, the regulation of their expression, their intracellular localization, and their tissue distribution. MCT4 is the main mediator for the efflux of L-lactate produced in the cell. Thus, MCT4 maintains the glycolytic phenotype of the cancer cell by supplying the molecular resources for tumor cell proliferation and promotes the acidification of the extracellular microenvironment from the co-transport of protons. A promising therapeutic strategy in anti-cancer drug design is the selective inhibition of MCT4 for the glycolytic suppression of solid tumors. A small number of studies indicate molecules for dual inhibition of MCT1 and MCT4; however, no selective inhibitor with high-affinity for MCT4 has been identified. In this study, we attempt to approach the structural characteristics of MCT4 through an in silico pipeline for molecular modelling and pharmacophore elucidation towards the identification of specific inhibitors as a novel anti-cancer strategy.     

加强寝室文化建设促进学风稳步提升

寝室文化是校园文化的一个重要和不可分割的组成部分,具有深刻的内涵和独特的功能。为培养学生的良好生活习惯,营造温馨的育人环境,激发学生的学习兴趣,高校要通过教育、管理、帮扶等措施加强寝室文化建设。通过创建先进的寝室文化,使大学生的综合素养不断得到提高,进而促进学风稳步提升。因此,要在大学校园中构建高质量的寝室文化,提升人才培养质量,把学生培养成合格的建设者和接班人,完成立德树人的根本任务。     

基于裂缝参数的钢筋混凝土预裂梁刚度试验研究

为研究钢筋混凝土简支梁桥跨中开裂后的刚度特性,开展不同裂缝名义损伤比下跨中预裂梁的力学试验。试件为现浇钢筋混凝土预裂梁,考虑了跨中3种不同长度a(a=8、18和26 mm)的预制裂缝。试验研究8 m标准跨径混凝土简支梁不同荷载级别下跨中预裂梁抗弯刚度折减系数k随裂缝名义损伤比λ和裂缝张开度w的演化规律。研究表明,不同试验工况下,k均随λ和w的增加而降低,且k的降低幅度在裂缝长度小于钢筋保护层时变化较小,在裂缝长度接近钢筋高度时快速降低,而在高于钢筋位置后则降幅减缓。在此基础上,提出跨中开裂钢筋混凝土简支梁桥抗弯刚度折减系数的计算公式。研究结果为该类梁桥跨中开裂后刚度性能的准确预测与评估提供了依据。     

不锈钢管件无模拉伸实验研究

对不锈钢管件无模拉伸变形时壁厚变化进行了实验研究 ,分析了不锈钢管件无模拉伸时壁厚变化的影响因素及影响规律。确定了不锈钢管件无模拉伸时壁厚变化经验公式。实验结果发现 ,不锈钢管件无模拉伸时 ,壁厚变化tf/t0 与Dif/Di,D0 f/D0 ,1-RS的值成正比 ,即 :tf/t0 =k1Dif/D0 =k2 D0 f/D0 =k3 1-RS。对于薄壁不锈钢管件 (当t0 /D0 <0 1)无模拉伸时 ,k1=k2 =k3 =1。     

The current perspective of the PA 1957 gas well pillar study and its implications for longwall gas well pillars

Many states rely upon the Pennsylvania 1957 Gas Well Pillar Study to evaluate the coal barrier surrounding gas wells. The study included 77 gas well failure cases that occurred in the Pittsburgh and Freeport coal seams over a 25-year span. At the time, coal was mined using the room-and-pillar mining method with full or partial pillar recovery, and square or rectangle pillars surrounding the gas wells were left to protect the wells. The study provided guidelines for pillar sizes under different overburden depths up to213 m(700 ft). The 1957 study has also been used to determine gas well pillar sizes in longwall mines since longwall mining began in the 1970 s. The original study was developed for room-and-pillar mining and could be applied to gas wells in longwall chain pillars under shallow cover. However, under deep cover, severe deformations in gas wells have occurred in longwall chain pillars. Presently, with a better understanding of coal pillar mechanics, new insight into subsidence movements induced by retreat mining, and advances in numerical modeling, it has become both critically important and feasible to evaluate the adequacy of the 1957 study for longwall gas well pillars. In this paper, the data from the 1957 study is analyzed from a new perspective by considering various factors, including overburden depth, failure location, failure time, pillar safety factor(SF), and floor pressure. The pillar SF and floor pressure are calculated by considering abutment pressure induced by full pillar recovery. A statistical analysis is performed to find correlations between various factors and helps identify the most significant factors for the stability of gas wells influenced by retreat mining. Through analyzing the data from the 1957 study, the guidelines for gas well pillars in the 1957 study are evaluated for their adequacy for roomand-pillar mining and their applicability to longwall mining. Numerical modeling is used to model the stability of gas wells by quantifying the mining-induced stresses in gas well casings. Results of this study indicate that the guidelines in the 1957 study may be appropriate for pillars protecting conventional gas wells in both room-and-pillar mining and longwall mining under overburden depths up to 213 m(700 ft),but may not be sufficient for protective pillars under deep cover. The current evaluation of the 1957 study provides not only insights about potential gas well failures caused by retreat mining but also implications for what critical considerations should be taken into account to protect gas wells in longwall mining.     

Application of an immobilized microbial consortium for the treatment of pharmaceutical wastewater: Batch-wise and continuous studies

In the present investigation, a microbial consortium consisting of four bacterial strains was selected for the treatment of pharmaceutical industry wastewater. The consortium was immobilized on a natural support matrix-Luffa and used for the treatment of real-time pharmaceutical wastewater in batch and continuous processes. The batch process was carried out to optimize the culture conditions and monitor the enzymatic activity. An array of enzymes such as alcohol dehydrogenase, aldehyde dehydrogenase, monooxygenase, catechol 2,3-dioxygenase and hydroquinol 1,2-dioxygenase were produced by the consortium. The kinetics of the degradation in the batch process was analyzed and it was noted to be a first-order reaction. For the continuous study, an aerobic fixed-film bioreactor (AFFBR) was utilized for a period of 61 days with variable hydraulic retention time (HRT) and organic loading rate (OLR). The immobilized microbes treated the wastewater by reducing the COD, phenolic contaminants and suspended solids. The OLR ranged between (0.56 ± 0.05) kg COD·m^-3 d^-1 to 3.35 kg COD·m^-3·d^-1 and the system achieved an average reduction of 96.8% of COD, 92.6% of phenolic compounds and 95.2% of suspended solids. Kinetics of the continuous process was interpreted by three different models, where the modified Stover Kincannon model and the Grau second-order model proved to be best fit for the degradation reaction with the constant for saturation value, KL being 95.12 g·L^-1·d^-1, the constant for maximum utilization of the substrate U_max being 90.01 g·L^-1 d^-1 and substrate removal constant K_Y was 1.074 d^-1 for both the models. GC-MS analysis confirmed that most of the organic contaminants were degraded into innocuous metabolites.